Cargando…

PGC1α-dependent NAD biosynthesis links oxidative metabolism to renal protection

The energetic burden of continuously concentrating solutes against gradients along the tubule may render the kidney especially vulnerable to ischemia. Indeed, acute kidney injury (AKI) affects 3% of all hospitalized patients.(1,2) Here we show that the mitochondrial biogenesis regulator, PGC1α,(3,4)...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tran, Mei T., Zsengeller, Zsuzsanna K., Berg, Anders H., Khankin, Eliyahu V., Bhasin, Manoj K., Kim, Wondong, Clish, Clary B., Stillman, Isaac E., Karumanchi, S. Ananth, Rhee, Eugene P., Parikh, Samir M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909121/ https://www.ncbi.nlm.nih.gov/pubmed/26982719 http://dx.doi.org/10.1038/nature17184

Ejemplares similares

TFEB-driven lysosomal biogenesis is pivotal for PGC1α-dependent renal stress resistance
por: Lynch, Matthew R., et al.
Publicado: (2019)

TFEB-driven lysosomal biogenesis is pivotal for PGC1α-dependent renal stress resistance
por: Lynch, Matthew R., et al.
Publicado: (2020)

Normalization of wall shear stress as a physiological mechanism for regulating maternal uterine artery expansive remodeling during pregnancy
por: Khankin, Eliyahu V., et al.
Publicado: (2021)

Transcriptional Patterns in Peritoneal Tissue of Encapsulating Peritoneal Sclerosis, a Complication of Chronic Peritoneal Dialysis
por: Reimold, Fabian R., et al.
Publicado: (2013)

Soluble fms-Like Tyrosine Kinase 1 Localization in Renal Biopsies of CKD
por: Zsengellér, Zsuzsanna K., et al.
Publicado: (2019)

Soluble Erythropoietin Receptor Contributes to Erythropoietin Resistance in End-Stage Renal Disease
por: Khankin, Eliyahu V., et al.
Publicado: (2010)

NAD(+) homeostasis in renal health and disease
por: Ralto, Kenneth M., et al.
Publicado: (2019)

First-Trimester Follistatin-Like-3 Levels in Pregnancies Complicated by Subsequent Gestational Diabetes Mellitus
por: Thadhani, Ravi, et al.
Publicado: (2010)

De novo NAD+ biosynthetic impairment in acute kidney injury in humans
por: Mehr, Ali Poyan, et al.
Publicado: (2018)

PAD4 Deficiency Decreases Inflammation and Susceptibility to Pregnancy Loss in a Mouse Model
por: Erpenbeck, Luise, et al.
Publicado: (2016)

Role of PGC-1α in the Mitochondrial NAD(+) Pool in Metabolic Diseases
por: Koh, Jin-Ho, et al.
Publicado: (2021)

NAD (+) biosynthesis, aging, and disease
por: Johnson, Sean, et al.
Publicado: (2018)

Urinary Neutrophil Gelatinase-Associated Lipocalin (NGAL) in Patients with Obstructive Sleep Apnea
por: Maski, Manish R., et al.
Publicado: (2016)

Metabolic reprogramming by the S-nitroso-CoA Reductase system protects from kidney injury
por: Zhou, Hua-Lin, et al.
Publicado: (2018)

The Impact of Carbamylation and Anemia on HbA(1c)’s Association With Renal Outcomes in Patients With Diabetes and Chronic Kidney Disease
por: Tang, Mengyao, et al.
Publicado: (2023)

Indoxyl sulfate in uremia: an old idea with updated concepts
por: Berg, Anders H., et al.
Publicado: (2022)

Construction of an Alternative NAD(+) De Novo Biosynthesis Pathway
por: Ding, Yong, et al.
Publicado: (2021)

The Prospective Synergy of Antitubercular Drugs With NAD Biosynthesis Inhibitors
por: Rohde, Kyle H., et al.
Publicado: (2021)

Early Evolutionary Selection of NAD Biosynthesis Pathway in Bacteria
por: Sharma, Suraj, et al.
Publicado: (2022)

Hypoxia-inducible factor 1 signaling drives placental aging and can provoke preterm labor
por: Ciampa, Erin J, et al.
Publicado: (2023)

Nicotinamide riboside with pterostilbene (NRPT) increases NAD(+) in patients with acute kidney injury (AKI): a randomized, double-blind, placebo-controlled, stepwise safety study of escalating doses of NRPT in patients with AKI
por: Simic, Petra, et al.
Publicado: (2020)

Lamin A/C impairments cause mitochondrial dysfunction by attenuating PGC1α and the NAMPT-NAD(+) pathway
por: Maynard, Scott, et al.
Publicado: (2022)

Excess Circulating Angiopoietin-2 May Contribute to Pulmonary Vascular Leak in Sepsis in Humans
por: Parikh, Samir M, et al.
Publicado: (2006)

Nicotinaldehyde, a Novel Precursor of NAD Biosynthesis, Abrogates the Anti-Cancer Activity of an NAD-Lowering Agent in Leukemia
por: Matsumoto, Saki, et al.
Publicado: (2023)

Cardiac Angiogenic Imbalance Leads to Peri-partum Cardiomyopathy
por: Patten, Ian S., et al.
Publicado: (2012)

NAD+ Biosynthesis Ameliorates a Zebrafish Model of Muscular Dystrophy
por: Goody, Michelle F., et al.
Publicado: (2012)

NAD+ Biosynthesis Impairment and Acute Kidney Injury after Major Vascular Surgery
por: Mede, Annmarie I., et al.
Publicado: (2023)

Rev1 contributes to proper mitochondrial function via the PARP-NAD(+)-SIRT1-PGC1α axis
por: Fakouri, Nima Borhan, et al.
Publicado: (2017)

Pgc-1α controls epidermal stem cell fate and skin repair by sustaining NAD(+) homeostasis during aging
por: Wong, Wesley, et al.
Publicado: (2022)

Metabolomics of renal venous plasma from individuals with unilateral renal artery stenosis and essential hypertension
por: Rhee, Eugene P., et al.
Publicado: (2015)

Metabolomics: an emerging but powerful tool for precision medicine
por: Clish, Clary B.
Publicado: (2015)

Metabolically distinct roles of NAD synthetase and NAD kinase define the essentiality of NAD and NADP in Mycobacterium tuberculosis
por: Sharma, Ritu, et al.
Publicado: (2023)

Mitochondrial oxidative capacity and NAD(+) biosynthesis are reduced in human sarcopenia across ethnicities
por: Migliavacca, Eugenia, et al.
Publicado: (2019)

Gene Transfers Shaped the Evolution of De Novo NAD(+) Biosynthesis in Eukaryotes
por: Ternes, Chad M., et al.
Publicado: (2014)

Cell stress response impairs de novo NAD(+) biosynthesis in the kidney
por: Bignon, Yohan, et al.
Publicado: (2022)

Potential Therapeutic Effects of NAMPT-Mediated NAD Biosynthesis in Depression In Vivo
por: Wang, Jue, et al.
Publicado: (2022)

Deletion of enzymes for de novo NAD (+) biosynthesis accelerated ovarian aging
por: Yang, Qingling, et al.
Publicado: (2023)

A reduced form of nicotinamide riboside defines a new path for NAD(+) biosynthesis and acts as an orally bioavailable NAD(+) precursor
por: Giroud-Gerbetant, Judith, et al.
Publicado: (2019)

Unusual Presentation of Hemophagocytic Lymphohistiocytosis in a Kidney Transplant Patient
por: Yang, Danwen, et al.
Publicado: (2019)

Author Correction: Rev1 contributes to proper mitochondrial function via the PARP-NAD(+)-SIRT1-PGC1α axis
por: Fakouri, Nima Borhan, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_lhhh1dick9vm6ovrhnum68stna