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Cyclization strategies of meditopes: affinity and diffraction studies of meditope–Fab complexes
Recently, a unique binding site for a cyclic 12-residue peptide was discovered within a cavity formed by the light and heavy chains of the cetuximab Fab domain. In order to better understand the interactions that drive this unique complex, a number of variants including the residues within the medit...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
International Union of Crystallography
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909242/ https://www.ncbi.nlm.nih.gov/pubmed/27303895 http://dx.doi.org/10.1107/S2053230X16007202 |