Network Analysis of Genome-Wide Selective Constraint Reveals a Gene Network Active in Early Fetal Brain Intolerant of Mutation

Using robust, integrated analysis of multiple genomic datasets, we show that genes depleted for non-synonymous de novo mutations form a subnetwork of 72 members under strong selective constraint. We further show this subnetwork is preferentially expressed in the early development of the human hippoc...

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Detalles Bibliográficos
Autores principales: Choi, Jinmyung, Shooshtari, Parisa, Samocha, Kaitlin E., Daly, Mark J., Cotsapas, Chris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909280/
https://www.ncbi.nlm.nih.gov/pubmed/27305007
http://dx.doi.org/10.1371/journal.pgen.1006121

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909280/
https://www.ncbi.nlm.nih.gov/pubmed/27305007
http://dx.doi.org/10.1371/journal.pgen.1006121

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