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Prolactin protects retinal pigment epithelium by inhibiting sirtuin 2-dependent cell death

The identification of pathways necessary for retinal pigment epithelium (RPE) function is fundamental to uncover therapies for blindness. Prolactin (PRL) receptors are expressed in the retina, but nothing is known about the role of PRL in RPE. Using the adult RPE 19 (ARPE-19) human cell line and mou...

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Detalles Bibliográficos
Autores principales: Meléndez García, Rodrigo, Arredondo Zamarripa, David, Arnold, Edith, Ruiz-Herrera, Xarubet, Noguez Imm, Ramsés, Baeza Cruz, German, Adán, Norma, Binart, Nadine, Riesgo-Escovar, Juan, Goffin, Vincent, Ordaz, Benito, Peña-Ortega, Fernando, Martínez-Torres, Ataúlfo, Clapp, Carmen, Thebault, Stéphanie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909382/
https://www.ncbi.nlm.nih.gov/pubmed/27322457
http://dx.doi.org/10.1016/j.ebiom.2016.03.048