USP11: A key regulator of cIAP2 stability and sensitivity to SMAC mimetics

The critical function of cellular inhibitor of apoptosis proteins (cIAPs) in the protection of cancer cells from numerous apoptotic stimuli prompted the development of second mitochondria-derived activator of caspases (SMAC) mimetics. We recently addressed a novel survival pathway in which cIAP2 is...

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Detalles Bibliográficos
Autores principales: Lee, Eun-Woo, Song, Jaewhan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909448/
https://www.ncbi.nlm.nih.gov/pubmed/27314066
http://dx.doi.org/10.1080/23723556.2015.1029829
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author Lee, Eun-Woo
Song, Jaewhan
author_facet Lee, Eun-Woo
Song, Jaewhan
author_sort Lee, Eun-Woo
collection PubMed
description The critical function of cellular inhibitor of apoptosis proteins (cIAPs) in the protection of cancer cells from numerous apoptotic stimuli prompted the development of second mitochondria-derived activator of caspases (SMAC) mimetics. We recently addressed a novel survival pathway in which cIAP2 is induced by tumor necrosis factor-α and is stabilized by its specific deubiquitylase, USP11, rendering cells resistant to SMAC mimetics.
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spelling pubmed-49094482016-06-16 USP11: A key regulator of cIAP2 stability and sensitivity to SMAC mimetics Lee, Eun-Woo Song, Jaewhan Mol Cell Oncol Author's View The critical function of cellular inhibitor of apoptosis proteins (cIAPs) in the protection of cancer cells from numerous apoptotic stimuli prompted the development of second mitochondria-derived activator of caspases (SMAC) mimetics. We recently addressed a novel survival pathway in which cIAP2 is induced by tumor necrosis factor-α and is stabilized by its specific deubiquitylase, USP11, rendering cells resistant to SMAC mimetics. Taylor & Francis 2015-04-14 /pmc/articles/PMC4909448/ /pubmed/27314066 http://dx.doi.org/10.1080/23723556.2015.1029829 Text en © 2016 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License http://creativecommons.org/licenses/by-nc/3.0/, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author's View
Lee, Eun-Woo
Song, Jaewhan
USP11: A key regulator of cIAP2 stability and sensitivity to SMAC mimetics
title USP11: A key regulator of cIAP2 stability and sensitivity to SMAC mimetics
title_full USP11: A key regulator of cIAP2 stability and sensitivity to SMAC mimetics
title_fullStr USP11: A key regulator of cIAP2 stability and sensitivity to SMAC mimetics
title_full_unstemmed USP11: A key regulator of cIAP2 stability and sensitivity to SMAC mimetics
title_short USP11: A key regulator of cIAP2 stability and sensitivity to SMAC mimetics
title_sort usp11: a key regulator of ciap2 stability and sensitivity to smac mimetics
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909448/
https://www.ncbi.nlm.nih.gov/pubmed/27314066
http://dx.doi.org/10.1080/23723556.2015.1029829
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AT songjaewhan usp11akeyregulatorofciap2stabilityandsensitivitytosmacmimetics

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