Targeting the PDGF-B/PDGFR-β Interface with Destruxin A5 to Selectively Block PDGF-BB/PDGFR-ββ Signaling and Attenuate Liver Fibrosis

PDGF-BB/PDGFR-ββ signaling plays very crucial roles in the process of many diseases such as liver fibrosis. However, drug candidates with selective affinities for PDGF-B/PDGFR-β remain deficient. Here, we identified a natural cyclopeptide termed destruxin A5 that effectively inhibits PDGF-BB-induced...

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Detalles Bibliográficos
Autores principales: Wang, Xingqi, Wu, Xuefeng, Zhang, Aihua, Wang, Shiyu, Hu, Chunhui, Chen, Wei, Shen, Yan, Tan, Renxiang, Sun, Yang, Xu, Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909612/
https://www.ncbi.nlm.nih.gov/pubmed/27322468
http://dx.doi.org/10.1016/j.ebiom.2016.03.042

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909612/
https://www.ncbi.nlm.nih.gov/pubmed/27322468
http://dx.doi.org/10.1016/j.ebiom.2016.03.042

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