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Phosphoinositide 3-Kinase (PI3K) Subunit p110δ Is Essential for Trophoblast Cell Differentiation and Placental Development in Mouse
Maternal PI3K p110δ has been implicated in smaller litter sizes in mice, but its underlying mechanism remains unclear. The placenta is an indispensable chimeric organ that supports mammalian embryonic development. Using a mouse model of genetic inactivation of PI3K p110δ (p110δ(D910A/D910A)), we sho...
Autores principales: | Hu, Xiwen, Li, Jiangchao, Zhang, Qianqian, Zheng, Lingyun, Wang, Guang, Zhang, Xiaohan, Zhang, Jingli, Gu, Quliang, Ye, Yuxiang, Guo, Sun-Wei, Yang, Xuesong, Wang, Lijing |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4910077/ https://www.ncbi.nlm.nih.gov/pubmed/27306493 http://dx.doi.org/10.1038/srep28201 |
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