Persistent neuronal Ube3a expression in the suprachiasmatic nucleus of Angelman syndrome model mice

Mutations or deletions of the maternal allele of the UBE3A gene cause Angelman syndrome (AS), a severe neurodevelopmental disorder. The paternal UBE3A/Ube3a allele becomes epigenetically silenced in most neurons during postnatal development in humans and mice; hence, loss of the maternal allele larg...

Descripción completa

Detalles Bibliográficos
Autores principales: Jones, Kelly A., Han, Ji Eun, DeBruyne, Jason P., Philpot, Benjamin D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4910164/
https://www.ncbi.nlm.nih.gov/pubmed/27306933
http://dx.doi.org/10.1038/srep28238

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4910164/
https://www.ncbi.nlm.nih.gov/pubmed/27306933
http://dx.doi.org/10.1038/srep28238

Ejemplares similares