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Persistent neuronal Ube3a expression in the suprachiasmatic nucleus of Angelman syndrome model mice
Mutations or deletions of the maternal allele of the UBE3A gene cause Angelman syndrome (AS), a severe neurodevelopmental disorder. The paternal UBE3A/Ube3a allele becomes epigenetically silenced in most neurons during postnatal development in humans and mice; hence, loss of the maternal allele larg...
Autores principales: | Jones, Kelly A., Han, Ji Eun, DeBruyne, Jason P., Philpot, Benjamin D. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4910164/ https://www.ncbi.nlm.nih.gov/pubmed/27306933 http://dx.doi.org/10.1038/srep28238 |
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