ELMO1 Directly Interacts with Gβγ Subunit to Transduce GPCR Signaling to Rac1 Activation in Chemotaxis

Diverse chemokines bind to G protein-coupled receptors (GPCRs) to activate the small GTPase Rac to regulate F-actin dynamics during chemotaxis. ELMO and Dock proteins form complexes that function as guanine nucleotide exchange factors (GEFs) for Rac activation. However, the linkage between GPCR acti...

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Detalles Bibliográficos
Autores principales: Wang, Youhong, Xu, Xuehua, Pan, Miao, Jin, Tian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4910590/
https://www.ncbi.nlm.nih.gov/pubmed/27313788
http://dx.doi.org/10.7150/jca.15118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4910590/
https://www.ncbi.nlm.nih.gov/pubmed/27313788
http://dx.doi.org/10.7150/jca.15118

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