Synthesis and Biological Evaluation of Novel Phosphatidylcholine Analogues Containing Monoterpene Acids as Potent Antiproliferative Agents

The synthesis of novel phosphatidylcholines with geranic and citronellic acids in sn-1 and sn-2 positions is described. The structured phospholipids were obtained in high yields (59–87%) and evaluated in vitro for their cytotoxic activity against several cancer cell lines of different origin: MV4-11...

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Autores principales: Gliszczyńska, Anna, Niezgoda, Natalia, Gładkowski, Witold, Czarnecka, Marta, Świtalska, Marta, Wietrzyk, Joanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911001/
https://www.ncbi.nlm.nih.gov/pubmed/27310666
http://dx.doi.org/10.1371/journal.pone.0157278
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author Gliszczyńska, Anna
Niezgoda, Natalia
Gładkowski, Witold
Czarnecka, Marta
Świtalska, Marta
Wietrzyk, Joanna
author_facet Gliszczyńska, Anna
Niezgoda, Natalia
Gładkowski, Witold
Czarnecka, Marta
Świtalska, Marta
Wietrzyk, Joanna
author_sort Gliszczyńska, Anna
collection PubMed
description The synthesis of novel phosphatidylcholines with geranic and citronellic acids in sn-1 and sn-2 positions is described. The structured phospholipids were obtained in high yields (59–87%) and evaluated in vitro for their cytotoxic activity against several cancer cell lines of different origin: MV4-11, A-549, MCF-7, LOVO, LOVO/DX, HepG2 and also towards non-cancer cell line BALB/3T3 (normal mice fibroblasts). The phosphatidylcholines modified with monoterpene acid showed a significantly higher antiproliferative activity than free monoterpene acids. The highest activity was observed for the terpene-phospholipids containing the isoprenoid acids in sn-1 position of phosphatidylcholine and palmitic acid in sn-2.
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spelling pubmed-49110012016-07-06 Synthesis and Biological Evaluation of Novel Phosphatidylcholine Analogues Containing Monoterpene Acids as Potent Antiproliferative Agents Gliszczyńska, Anna Niezgoda, Natalia Gładkowski, Witold Czarnecka, Marta Świtalska, Marta Wietrzyk, Joanna PLoS One Research Article The synthesis of novel phosphatidylcholines with geranic and citronellic acids in sn-1 and sn-2 positions is described. The structured phospholipids were obtained in high yields (59–87%) and evaluated in vitro for their cytotoxic activity against several cancer cell lines of different origin: MV4-11, A-549, MCF-7, LOVO, LOVO/DX, HepG2 and also towards non-cancer cell line BALB/3T3 (normal mice fibroblasts). The phosphatidylcholines modified with monoterpene acid showed a significantly higher antiproliferative activity than free monoterpene acids. The highest activity was observed for the terpene-phospholipids containing the isoprenoid acids in sn-1 position of phosphatidylcholine and palmitic acid in sn-2. Public Library of Science 2016-06-16 /pmc/articles/PMC4911001/ /pubmed/27310666 http://dx.doi.org/10.1371/journal.pone.0157278 Text en © 2016 Gliszczyńska et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Gliszczyńska, Anna
Niezgoda, Natalia
Gładkowski, Witold
Czarnecka, Marta
Świtalska, Marta
Wietrzyk, Joanna
Synthesis and Biological Evaluation of Novel Phosphatidylcholine Analogues Containing Monoterpene Acids as Potent Antiproliferative Agents
title Synthesis and Biological Evaluation of Novel Phosphatidylcholine Analogues Containing Monoterpene Acids as Potent Antiproliferative Agents
title_full Synthesis and Biological Evaluation of Novel Phosphatidylcholine Analogues Containing Monoterpene Acids as Potent Antiproliferative Agents
title_fullStr Synthesis and Biological Evaluation of Novel Phosphatidylcholine Analogues Containing Monoterpene Acids as Potent Antiproliferative Agents
title_full_unstemmed Synthesis and Biological Evaluation of Novel Phosphatidylcholine Analogues Containing Monoterpene Acids as Potent Antiproliferative Agents
title_short Synthesis and Biological Evaluation of Novel Phosphatidylcholine Analogues Containing Monoterpene Acids as Potent Antiproliferative Agents
title_sort synthesis and biological evaluation of novel phosphatidylcholine analogues containing monoterpene acids as potent antiproliferative agents
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911001/
https://www.ncbi.nlm.nih.gov/pubmed/27310666
http://dx.doi.org/10.1371/journal.pone.0157278
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