Understanding and Controlling Sialylation in a CHO Fc-Fusion Process

A Chinese hamster ovary (CHO) bioprocess, where the product is a sialylated Fc-fusion protein, was operated at pilot and manufacturing scale and significant variation of sialylation level was observed. In order to more tightly control glycosylation profiles, we sought to identify the cause of variab...

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Detalles Bibliográficos
Autores principales: Lewis, Amanda M., Croughan, William D., Aranibar, Nelly, Lee, Alison G., Warrack, Bethanne, Abu-Absi, Nicholas R., Patel, Rutva, Drew, Barry, Borys, Michael C., Reily, Michael D., Li, Zheng Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911072/
https://www.ncbi.nlm.nih.gov/pubmed/27310468
http://dx.doi.org/10.1371/journal.pone.0157111

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911072/
https://www.ncbi.nlm.nih.gov/pubmed/27310468
http://dx.doi.org/10.1371/journal.pone.0157111

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