HLA class I molecular variation and peptide-binding properties suggest a model of joint divergent asymmetric selection

The main function of HLA class I molecules is to present pathogen-derived peptides to cytotoxic T lymphocytes. This function is assumed to drive the maintenance of an extraordinary amount of polymorphism at each HLA locus, providing an immune advantage to heterozygote individuals capable to present...

Descripción completa

Detalles Bibliográficos
Autores principales: Buhler, Stéphane, Nunes, José Manuel, Sanchez-Mazas, Alicia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911380/
https://www.ncbi.nlm.nih.gov/pubmed/27233953
http://dx.doi.org/10.1007/s00251-016-0918-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911380/
https://www.ncbi.nlm.nih.gov/pubmed/27233953
http://dx.doi.org/10.1007/s00251-016-0918-x

Ejemplares similares