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HLA class I molecular variation and peptide-binding properties suggest a model of joint divergent asymmetric selection

The main function of HLA class I molecules is to present pathogen-derived peptides to cytotoxic T lymphocytes. This function is assumed to drive the maintenance of an extraordinary amount of polymorphism at each HLA locus, providing an immune advantage to heterozygote individuals capable to present...

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Detalles Bibliográficos
Autores principales:	Buhler, Stéphane, Nunes, José Manuel, Sanchez-Mazas, Alicia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2016
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911380/ https://www.ncbi.nlm.nih.gov/pubmed/27233953 http://dx.doi.org/10.1007/s00251-016-0918-x

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