Long-term exposure to abnormal glucose levels alters drug metabolism pathways and insulin sensitivity in primary human hepatocytes

Hyperglycemia in type 2 diabetes mellitus has been linked to non-alcoholic fatty liver disease, which can progress to inflammation, fibrosis/cirrhosis, and hepatocellular carcinoma. Understanding how chronic hyperglycemia affects primary human hepatocytes (PHHs) can facilitate the development of the...

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Detalles Bibliográficos
Autores principales: Davidson, Matthew D., Ballinger, Kimberly R., Khetani, Salman R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911593/
https://www.ncbi.nlm.nih.gov/pubmed/27312339
http://dx.doi.org/10.1038/srep28178

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911593/
https://www.ncbi.nlm.nih.gov/pubmed/27312339
http://dx.doi.org/10.1038/srep28178

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