Antiproliferation of berberine is mediated by epigenetic modification of constitutive androstane receptor (CAR) metabolic pathway in hepatoma cells

Constitutive androstane receptor (CAR) regulates hepatic xenobiotic and energy metabolism, as well as promotes cell growth and hepatocarcinogenesis. Berberine is an ancient multipotent alkaloid drug which derived from Coptis chinensis plants. Here we report that berberine is able to be cellular upta...

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Detalles Bibliográficos
Autores principales: Zhang, Lei, Miao, Xiao-Jie, Wang, Xin, Pan, Hai-Hui, Li, Pu, Ren, Hong, Jia, Yong-Rui, Lu, Chuang, Wang, Hong-Bing, Yuan, Lan, Zhang, Guo-Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911599/
https://www.ncbi.nlm.nih.gov/pubmed/27311637
http://dx.doi.org/10.1038/srep28116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911599/
https://www.ncbi.nlm.nih.gov/pubmed/27311637
http://dx.doi.org/10.1038/srep28116

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