Homeobox NKX2-3 promotes marginal-zone lymphomagenesis by activating B-cell receptor signalling and shaping lymphocyte dynamics

NKX2 homeobox family proteins have a role in cancer development. Here we show that NKX2-3 is overexpressed in tumour cells from a subset of patients with marginal-zone lymphomas, but not with other B-cell malignancies. While Nkx2-3-deficient mice exhibit the absence of marginal-zone B cells, transge...

Descripción completa

Detalles Bibliográficos
Autores principales: Robles, Eloy F., Mena-Varas, Maria, Barrio, Laura, Merino-Cortes, Sara V., Balogh, Péter, Du, Ming-Qing, Akasaka, Takashi, Parker, Anton, Roa, Sergio, Panizo, Carlos, Martin-Guerrero, Idoia, Siebert, Reiner, Segura, Victor, Agirre, Xabier, Macri-Pellizeri, Laura, Aldaz, Beatriz, Vilas-Zornoza, Amaia, Zhang, Shaowei, Moody, Sarah, Calasanz, Maria Jose, Tousseyn, Thomas, Broccardo, Cyril, Brousset, Pierre, Campos-Sanchez, Elena, Cobaleda, Cesar, Sanchez-Garcia, Isidro, Fernandez-Luna, Jose Luis, Garcia-Muñoz, Ricardo, Pena, Esther, Bellosillo, Beatriz, Salar, Antonio, Baptista, Maria Joao, Hernandez-Rivas, Jesús Maria, Gonzalez, Marcos, Terol, Maria Jose, Climent, Joan, Ferrandez, Antonio, Sagaert, Xavier, Melnick, Ari M., Prosper, Felipe, Oscier, David G., Carrasco, Yolanda R., Dyer, Martin J. S., Martinez-Climent, Jose A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911677/
https://www.ncbi.nlm.nih.gov/pubmed/27297662
http://dx.doi.org/10.1038/ncomms11889

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911677/
https://www.ncbi.nlm.nih.gov/pubmed/27297662
http://dx.doi.org/10.1038/ncomms11889

Ejemplares similares