Activation of PKR by short stem–loop RNAs containing single-stranded arms

Protein kinase R (PKR) is a central component of the innate immunity antiviral pathway and is activated by dsRNA. PKR contains a C-terminal kinase domain and two tandem dsRNA binding domains. In the canonical activation model, binding of multiple PKR monomers to dsRNA enhances dimerization of the ki...

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Detalles Bibliográficos
Autores principales: Mayo, Christopher B., Wong, C. Jason, Lopez, Prisma E., Lary, Jeffrey W., Cole, James L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911914/
https://www.ncbi.nlm.nih.gov/pubmed/27208315
http://dx.doi.org/10.1261/rna.053348.115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911914/
https://www.ncbi.nlm.nih.gov/pubmed/27208315
http://dx.doi.org/10.1261/rna.053348.115

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