Genetic requirement for Mycl and efficacy of RNA Pol I inhibition in mouse models of small cell lung cancer

Small cell lung cancer (SCLC) is a devastating neuroendocrine carcinoma. MYCL (L-Myc) is frequently amplified in human SCLC, but its roles in SCLC progression are poorly understood. We isolated preneoplastic neuroendocrine cells from a mouse model of SCLC and found that ectopic expression of L-Myc,...

Descripción completa

Detalles Bibliográficos
Autores principales: Kim, Dong-Wook, Wu, Nan, Kim, Young-Chul, Cheng, Pei Feng, Basom, Ryan, Kim, Dongkyoon, Dunn, Colin T., Lee, Anastasia Y., Kim, Keebeom, Lee, Chang Sup, Singh, Andrew, Gazdar, Adi F., Harris, Chris R., Eisenman, Robert N., Park, Kwon-Sik, MacPherson, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911928/
https://www.ncbi.nlm.nih.gov/pubmed/27298335
http://dx.doi.org/10.1101/gad.279307.116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911928/
https://www.ncbi.nlm.nih.gov/pubmed/27298335
http://dx.doi.org/10.1101/gad.279307.116

Ejemplares similares