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Genetic requirement for Mycl and efficacy of RNA Pol I inhibition in mouse models of small cell lung cancer

Small cell lung cancer (SCLC) is a devastating neuroendocrine carcinoma. MYCL (L-Myc) is frequently amplified in human SCLC, but its roles in SCLC progression are poorly understood. We isolated preneoplastic neuroendocrine cells from a mouse model of SCLC and found that ectopic expression of L-Myc,...

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Detalles Bibliográficos
Autores principales:	Kim, Dong-Wook, Wu, Nan, Kim, Young-Chul, Cheng, Pei Feng, Basom, Ryan, Kim, Dongkyoon, Dunn, Colin T., Lee, Anastasia Y., Kim, Keebeom, Lee, Chang Sup, Singh, Andrew, Gazdar, Adi F., Harris, Chris R., Eisenman, Robert N., Park, Kwon-Sik, MacPherson, David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911928/ https://www.ncbi.nlm.nih.gov/pubmed/27298335 http://dx.doi.org/10.1101/gad.279307.116

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