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Generalized Liver- and Blood-Derived CD8(+) T-Cell Impairment in Response to Cytokines in Chronic Hepatitis C Virus Infection

Generalized CD8(+) T-cell impairment in chronic hepatitis C virus (HCV) infection and the contribution of liver-infiltrating CD8(+) T-cells to the immunopathogenesis of this infection remain poorly understood. It is hypothesized that this impairment is partially due to reduced CD8(+) T-cell activity...

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Detalles Bibliográficos
Autores principales: Burke Schinkel, Stephanie C., Carrasco-Medina, Lorna, Cooper, Curtis L., Crawley, Angela M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4912163/
https://www.ncbi.nlm.nih.gov/pubmed/27315061
http://dx.doi.org/10.1371/journal.pone.0157055