Polymerase θ is a robust terminal transferase that oscillates between three different mechanisms during end-joining

DNA polymerase θ (Polθ) promotes insertion mutations during alternative end-joining (alt-EJ) by an unknown mechanism. Here, we discover that mammalian Polθ transfers nucleotides to the 3’ terminus of DNA during alt-EJ in vitro and in vivo by oscillating between three different modes of terminal tran...

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Detalles Bibliográficos
Autores principales: Kent, Tatiana, Mateos-Gomez, Pedro A, Sfeir, Agnel, Pomerantz, Richard T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4912351/
https://www.ncbi.nlm.nih.gov/pubmed/27311885
http://dx.doi.org/10.7554/eLife.13740

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4912351/
https://www.ncbi.nlm.nih.gov/pubmed/27311885
http://dx.doi.org/10.7554/eLife.13740

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