Sigma-1 receptor ligands control a switch between passive and active threat responses

Humans and many animals exhibit freezing behavior in response to threatening stimuli. In humans, inappropriate threat responses are fundamental characteristics of several mental illnesses. To identify small molecules that modulate threat responses, we developed a high-throughput behavioral assay in...

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Detalles Bibliográficos
Autores principales: Rennekamp, Andrew J., Huang, Xi-Ping, Wang, You, Patel, Samir, Lorello, Paul J., Cade, Lindsay, Gonzales, Andrew P. W., Yeh, Jing-Ruey Joanna, Caldarone, Barbara J., Roth, Bryan L., Kokel, David, Peterson, Randall T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4912403/
https://www.ncbi.nlm.nih.gov/pubmed/27239788
http://dx.doi.org/10.1038/nchembio.2089

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4912403/
https://www.ncbi.nlm.nih.gov/pubmed/27239788
http://dx.doi.org/10.1038/nchembio.2089

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