Cargando…

Sigma-1 receptor ligands control a switch between passive and active threat responses

Humans and many animals exhibit freezing behavior in response to threatening stimuli. In humans, inappropriate threat responses are fundamental characteristics of several mental illnesses. To identify small molecules that modulate threat responses, we developed a high-throughput behavioral assay in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rennekamp, Andrew J., Huang, Xi-Ping, Wang, You, Patel, Samir, Lorello, Paul J., Cade, Lindsay, Gonzales, Andrew P. W., Yeh, Jing-Ruey Joanna, Caldarone, Barbara J., Roth, Bryan L., Kokel, David, Peterson, Randall T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4912403/ https://www.ncbi.nlm.nih.gov/pubmed/27239788 http://dx.doi.org/10.1038/nchembio.2089

Ejemplares similares

Zebrafish behavioral profiling identifies multi-target antipsychotic-like compounds
por: Bruni, Giancarlo, et al.
Publicado: (2016)

Targeted gene disruption in somatic zebrafish cells using engineered TALENs
por: Sander, Jeffry D., et al.
Publicado: (2011)

Highly efficient generation of heritable zebrafish gene mutations using homo- and heterodimeric TALENs
por: Cade, Lindsay, et al.
Publicado: (2012)

Pharmacology and Therapeutic Potential of Sigma(1) Receptor Ligands
por: Cobos, E.J, et al.
Publicado: (2008)

The role of threat anticipation in the development of psychopathology in adolescence: findings from the SIGMA Study
por: Paetzold, Isabell, et al.
Publicado: (2022)

Identification of a Novel Retinoid by Small Molecule Screening with Zebrafish Embryos
por: Sachidanandan, Chetana, et al.
Publicado: (2008)

Synthesis, Computational Insights, and Evaluation of Novel Sigma Receptors Ligands
por: Dichiara, Maria, et al.
Publicado: (2023)

Sigma Receptor Ligands Prevent COVID Mortality In Vivo: Implications for Future Therapeutics
por: Berkowitz, Reed L., et al.
Publicado: (2023)

Non-medical switching an unmitigated threat to patient care
por: Baum, Dr. Seth J.
Publicado: (2023)

Sigma-2 receptor ligands QSAR model dataset
por: Rescifina, Antonio, et al.
Publicado: (2017)

Defining the ligand-dependent proximatome of the sigma 1 receptor
por: Zhao, Jing, et al.
Publicado: (2023)

Proteolysis of Sars-Associated Coronavirus Spike Glycoprotein
por: Simmons, Graham, et al.
Publicado: (2006)

High-throughput screening for selective appetite modulators: A multibehavioral and translational drug discovery strategy
por: Jordi, Josua, et al.
Publicado: (2018)

Sensitivity towards Fear of Electric Shock in Passive Threat Situations
por: Ring, Patrick, et al.
Publicado: (2015)

Sigma-2 ligands induce tumour cell death by multiple signalling pathways
por: Zeng, C, et al.
Publicado: (2012)

Design of low power and low area passive sigma delta modulators for audio applications
por: Fouto, David, et al.
Publicado: (2017)

The Oligomeric States of the Purified Sigma-1 Receptor Are Stabilized by Ligands
por: Gromek, Katarzyna A., et al.
Publicado: (2014)

Sigma Receptor (σR) Ligands with Antiproliferative and Anticancer Activity
por: Georgiadis, Markos-Orestis, et al.
Publicado: (2017)

Repurposing Sigma-1 Receptor Ligands for COVID-19 Therapy?
por: Vela, José Miguel
Publicado: (2020)

Effects of Sigma-1 Receptor Ligands on Peripheral Nerve Regeneration
por: Cottilli, Patrick, et al.
Publicado: (2022)

Reprogramming Eukaryotic Translation with Ligand-Responsive Synthetic RNA Switches
por: Anzalone, Andrew V., et al.
Publicado: (2016)

Design Principles for Ligand-Sensing, Conformation-Switching Ribozymes
por: Chen, Xi, et al.
Publicado: (2009)

$\Sigma^{+}$, $\Sigma^{0}$ and $\Sigma^{-}$ hyperon production in hadronic $Z^{0}$ decays
por: Alexander, Gideon, et al.
Publicado: (1996)

Zebrafish behavioural profiling identifies GABA and serotonin receptor ligands related to sedation and paradoxical excitation
por: McCarroll, Matthew N., et al.
Publicado: (2019)

Transfer of naturally acquired specific passive immunity against Anaplasma phagocytophilum in foals in Southeastern Pennsylvania and Northern Maryland
por: Rule, Emily K., et al.
Publicado: (2023)

Discovery of AD258 as a Sigma Receptor Ligand with Potent Antiallodynic Activity
por: Dichiara, Maria, et al.
Publicado: (2023)

Cytotoxicity Profiles and Neuroprotective Properties of the Novel Ifenprodil Analogues as Sigma Ligands
por: Zampieri, Daniele, et al.
Publicado: (2023)

Sigma-1 and Sigma-2 receptor ligands induce apoptosis and autophagy but have opposite effect on cell proliferation in uveal melanoma
por: Longhitano, Lucia, et al.
Publicado: (2017)

Hazards of Using Masking Protocols When Performing Ligand Binding Assays: Lessons From the Sigma-1 and Sigma-2 Receptors
por: Abbas, Haider, et al.
Publicado: (2020)

Selectivity profile comparison for certain γ-butyrolactone and oxazolidinone-based ligands on a sigma 2 receptor over sigma 1: a molecular docking approach
por: Bhandare, Richie R., et al.
Publicado: (2022)

Can higher twist be measured in R = sigma$_{L}$/sigma$_{T}$?
por: Miramontes, J L, et al.
Publicado: (1986)

Protein level identification of the Listeria monocytogenes Sigma H, Sigma L, and Sigma C regulons
por: Mujahid, Sana, et al.
Publicado: (2013)

Engineered CRISPR-Cas9 nucleases with altered PAM specificities
por: Kleinstiver, Benjamin P., et al.
Publicado: (2015)

SIGMA 76
por: Reinfelds, J, et al.
Publicado: (1977)

Chemical Informatics and Target Identification in a Zebrafish Phenotypic Screen
por: Laggner, Christian, et al.
Publicado: (2011)

Morphing of Ibogaine: A Successful Attempt into the Search for Sigma-2 Receptor Ligands
por: Floresta, Giuseppe, et al.
Publicado: (2019)

Sigma-1 Receptor Modulation by Ligands Coordinates Cancer Cell Energy Metabolism
por: Oflaz, Furkan E., et al.
Publicado: (2022)

The Sigma Enigma: A Narrative Review of Sigma Receptors
por: Pergolizzi, Joseph, et al.
Publicado: (2023)

Partnering on vaccines to counter multi-drug resistant threats: Workshop proceedings, Biomedical Advanced Research and Development Authority
por: Bergmann, Julie N., et al.
Publicado: (2022)

Complement activation by gold nanoparticles passivated with polyelectrolyte ligands
por: Quach, Quang Huy, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_8cct65lor5rq6dhkmkd2av6lbb