The Anti-tumor Toxin CD437 is a Direct Inhibitor of DNA Polymerase α

CD437 is a retinoid-like small molecule that selectively induces apoptosis in cancer but not normal cells through an unknown mechanism. We used a forward genetic strategy to discover mutations in POLA1 that coincide with CD437 resistance (POLA1(R)). Introduction of one of these mutations into cancer...

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Detalles Bibliográficos
Autores principales: Han, Ting, Goralski, Maria, Capota, Emanuela, Padrick, Shae B., Kim, Jiwoong, Xie, Yang, Nijhawan, Deepak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4912453/
https://www.ncbi.nlm.nih.gov/pubmed/27182663
http://dx.doi.org/10.1038/nchembio.2082

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4912453/
https://www.ncbi.nlm.nih.gov/pubmed/27182663
http://dx.doi.org/10.1038/nchembio.2082

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