Cargando…
The Anti-tumor Toxin CD437 is a Direct Inhibitor of DNA Polymerase α
CD437 is a retinoid-like small molecule that selectively induces apoptosis in cancer but not normal cells through an unknown mechanism. We used a forward genetic strategy to discover mutations in POLA1 that coincide with CD437 resistance (POLA1(R)). Introduction of one of these mutations into cancer...
| Autores principales: | , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2016
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4912453/ https://www.ncbi.nlm.nih.gov/pubmed/27182663 http://dx.doi.org/10.1038/nchembio.2082 |