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The calcineruin inhibitor cyclosporine a synergistically enhances the susceptibility of Candida albicans biofilms to fluconazole by multiple mechanisms

BACKGROUND: Biofilms produced by Candida albicans (C. albicans) are intrinsically resistant to fungicidal agents, which are a main cause of the pathogenesis of catheter infections. Several lines of evidence have demonstrated that calcineurin inhibitor FK506 or cyclosporine A (CsA) can remarkably enh...

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Detalles Bibliográficos
Autores principales: Jia, Wei, Zhang, Haiyun, Li, Caiyun, Li, Gang, Liu, Xiaoming, Wei, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4912705/
https://www.ncbi.nlm.nih.gov/pubmed/27316338
http://dx.doi.org/10.1186/s12866-016-0728-1