Enhanced inhibition of clonogenic survival of human medulloblastoma cells by multimodal treatment with ionizing irradiation, epigenetic modifiers, and differentiation-inducing drugs

BACKGROUND: Medulloblastoma (MB) is the most common pediatric brain tumor. Current treatment regimes consisting of primary surgery followed by radio- and chemotherapy, achieve 5-year overall survival rates of only about 60 %. Therapy-induced endocrine and neurocognitive deficits are common late adve...

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Detalles Bibliográficos
Autores principales: Patties, Ina, Kortmann, Rolf-Dieter, Menzel, Franziska, Glasow, Annegret
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4912728/
https://www.ncbi.nlm.nih.gov/pubmed/27317342
http://dx.doi.org/10.1186/s13046-016-0376-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4912728/
https://www.ncbi.nlm.nih.gov/pubmed/27317342
http://dx.doi.org/10.1186/s13046-016-0376-1

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