Detection and sequence/structure mapping of biophysical constraints to protein variation in saturated mutational libraries and protein sequence alignments with a dedicated server

BACKGROUND: Protein variability can now be studied by measuring high-resolution tolerance-to-substitution maps and fitness landscapes in saturated mutational libraries. But these rich and expensive datasets are typically interpreted coarsely, restricting detailed analyses to positions of extremely h...

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Detalles Bibliográficos
Autores principales: Abriata, Luciano A., Bovigny, Christophe, Dal Peraro, Matteo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4912743/
https://www.ncbi.nlm.nih.gov/pubmed/27315797
http://dx.doi.org/10.1186/s12859-016-1124-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4912743/
https://www.ncbi.nlm.nih.gov/pubmed/27315797
http://dx.doi.org/10.1186/s12859-016-1124-4

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