Flavin-Dependent Thymidylate Synthase as a New Antibiotic Target

In humans de novo synthesis of 2′-deoxythymidine-5′-monophosphate (dTMP), an essential building block of DNA, utilizes an enzymatic pathway requiring thymidylate synthase (TSase) and dihydrofolate reductase (DHFR). The enzyme flavin-dependent thymidylate synthase (FDTS) represents an alternative enz...

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Detalles Bibliográficos
Autores principales: Choi, Michael, Karunaratne, Kalani, Kohen, Amnon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4913046/
https://www.ncbi.nlm.nih.gov/pubmed/27213314
http://dx.doi.org/10.3390/molecules21050654

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4913046/
https://www.ncbi.nlm.nih.gov/pubmed/27213314
http://dx.doi.org/10.3390/molecules21050654

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