Cargando…
CD8(+) T cells induce platelet clearance in the liver via platelet desialylation in immune thrombocytopenia
In addition to antiplatelet autoantibodies, CD8(+) cytotoxic T lymphocytes (CTLs) play an important role in the increased platelet destruction in immune thrombocytopenia (ITP). Recent studies have highlighted that platelet desialylation leads to platelet clearance via hepatocyte asialoglycoprotein r...
Autores principales: | Qiu, Jihua, Liu, Xuena, Li, Xiaoqing, Zhang, Xu, Han, Panpan, Zhou, Hai, Shao, Linlin, Hou, Yu, Min, Yanan, Kong, Zhangyuan, Wang, Yawen, Wei, Yu, Liu, Xinguang, Ni, Heyu, Peng, Jun, Hou, Ming |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4913243/ https://www.ncbi.nlm.nih.gov/pubmed/27321376 http://dx.doi.org/10.1038/srep27445 |
Ejemplares similares
-
Desialylation is a mechanism of Fc-independent platelet clearance and a therapeutic target in immune thrombocytopenia
por: Li, June, et al.
Publicado: (2015) -
Platelet desialylation correlates with efficacy of first-line therapies for immune thrombocytopenia
por: Tao, Lili, et al.
Publicado: (2017) -
Desialylated Platelet Clearance in the Liver is a Novel Mechanism of Systemic Immunosuppression
por: Li, June, et al.
Publicado: (2023) -
Platelet desialylation and TFH cells–the novel pathway of immune thrombocytopenia
por: Chen, Yuwen, et al.
Publicado: (2021) -
Antiplatelet antibody predicts platelet desialylation and apoptosis in immune thrombocytopenia
por: Zheng, Shiying Silvia, et al.
Publicado: (2022)