Effect of the sphingosine kinase 1 selective inhibitor, PF-543 on arterial and cardiac remodelling in a hypoxic model of pulmonary arterial hypertension

Recent studies have demonstrated that the expression of sphingosine kinase 1, the enzyme that catalyses formation of the bioactive lipid, sphingosine 1-phosphate, is increased in lungs from patients with pulmonary arterial hypertension. In addition, Sk1(−/−) mice are protected from hypoxic-induced p...

Descripción completa

Detalles Bibliográficos
Autores principales: MacRitchie, Neil, Volpert, Giora, Al Washih, Mohammed, Watson, David G., Futerman, Anthony H., Kennedy, Simon, Pyne, Susan, Pyne, Nigel J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science Ltd 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4913619/
https://www.ncbi.nlm.nih.gov/pubmed/27063355
http://dx.doi.org/10.1016/j.cellsig.2016.03.014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4913619/
https://www.ncbi.nlm.nih.gov/pubmed/27063355
http://dx.doi.org/10.1016/j.cellsig.2016.03.014

Ejemplares similares