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Effect of the sphingosine kinase 1 selective inhibitor, PF-543 on arterial and cardiac remodelling in a hypoxic model of pulmonary arterial hypertension

Recent studies have demonstrated that the expression of sphingosine kinase 1, the enzyme that catalyses formation of the bioactive lipid, sphingosine 1-phosphate, is increased in lungs from patients with pulmonary arterial hypertension. In addition, Sk1(−/−) mice are protected from hypoxic-induced p...

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Detalles Bibliográficos
Autores principales:	MacRitchie, Neil, Volpert, Giora, Al Washih, Mohammed, Watson, David G., Futerman, Anthony H., Kennedy, Simon, Pyne, Susan, Pyne, Nigel J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Science Ltd 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4913619/ https://www.ncbi.nlm.nih.gov/pubmed/27063355 http://dx.doi.org/10.1016/j.cellsig.2016.03.014

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