Dual targeting of p53 and c-Myc selectively eliminates leukaemic stem cells

Chronic myeloid leukaemia (CML) arises following transformation of a haemopoietic stem cell (HSC) by protein-tyrosine kinase BCR-ABL1. Direct inhibition of BCR-ABL1 kinase has revolutionized disease management, but fails to eradicate leukaemic stem cells (LSC), which maintain CML. LSC are independen...

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Detalles Bibliográficos
Autores principales: Abraham, Sheela A, Hopcroft, Lisa EM, Carrick, Emma, Drotar, Mark E, Dunn, Karen, Williamson, Andrew JK, Korfi, Koorosh, Baquero, Pablo, Park, Laura E, Scott, Mary T, Pellicano, Francesca, Pierce, Andrew, Copland, Mhairi, Nourse, Craig, Grimmond, Sean M, Vetrie, David, Whetton, Anthony D, Holyoake, Tessa L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4913876/
https://www.ncbi.nlm.nih.gov/pubmed/27281222
http://dx.doi.org/10.1038/nature18288

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4913876/
https://www.ncbi.nlm.nih.gov/pubmed/27281222
http://dx.doi.org/10.1038/nature18288

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