Cargando…

Dual targeting of p53 and c-Myc selectively eliminates leukaemic stem cells

Chronic myeloid leukaemia (CML) arises following transformation of a haemopoietic stem cell (HSC) by protein-tyrosine kinase BCR-ABL1. Direct inhibition of BCR-ABL1 kinase has revolutionized disease management, but fails to eradicate leukaemic stem cells (LSC), which maintain CML. LSC are independen...

Descripción completa

Detalles Bibliográficos
Autores principales:	Abraham, Sheela A, Hopcroft, Lisa EM, Carrick, Emma, Drotar, Mark E, Dunn, Karen, Williamson, Andrew JK, Korfi, Koorosh, Baquero, Pablo, Park, Laura E, Scott, Mary T, Pellicano, Francesca, Pierce, Andrew, Copland, Mhairi, Nourse, Craig, Grimmond, Sean M, Vetrie, David, Whetton, Anthony D, Holyoake, Tessa L
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4913876/ https://www.ncbi.nlm.nih.gov/pubmed/27281222 http://dx.doi.org/10.1038/nature18288

Ejemplares similares

The Antiproliferative Activity of Kinase Inhibitors in Chronic Myeloid Leukemia Cells Is Mediated by FOXO Transcription Factors
por: Pellicano, Francesca, et al.
Publicado: (2014)

Tyrosine Kinase Inhibitor Independent Gene Expression Signature in CML Offers New Targets for LSPC Eradication Therapy
por: Gómez-Castañeda, Eduardo, et al.
Publicado: (2022)

Validating a network hub in leukaemia stem cells
por: Hopcroft, Lisa E., et al.
Publicado: (2017)

Pyruvate anaplerosis is a targetable vulnerability in persistent leukaemic stem cells
por: Rattigan, Kevin M., et al.
Publicado: (2023)

Oncogenic MYC amplifies mitotic perturbations
por: Littler, Samantha, et al.
Publicado: (2019)

Arginine dependency is a therapeutically exploitable vulnerability in chronic myeloid leukaemic stem cells
por: Rattigan, Kevin M, et al.
Publicado: (2023)

Assembling defenses against therapy-resistant leukemic stem cells: Bcl6 joins the ranks
por: Pellicano, Francesca, et al.
Publicado: (2011)

Pseudo-Leukæmic Lymphosarcoma
por: Ainley, Norman J.
Publicado: (1949)

Single-cell immunofluorescence assay for terminal transferase: Human leukaemic and non-leukaemic cells
por: Okamura, S., et al.
Publicado: (1980)

Dasatinib inhibits leukaemic cell survival by decreasing PRH/Hhex phosphorylation resulting in increased repression of VEGF signalling genes
por: Noy, Peter, et al.
Publicado: (2012)

Proceedings: Surface antigens of leukaemic cells.
por: Greaves, M. F.
Publicado: (1975)

Morphological study of the ovaries of leukaemic children.
por: Himelstein-Braw, R., et al.
Publicado: (1978)

Targeting mitochondrial oxidative phosphorylation eradicates therapy-resistant chronic myeloid leukemic stem cells
por: Kuntz, Elodie M., et al.
Publicado: (2017)

Different distribution of adriamycin in normal and leukaemic rats.
por: Sonneveld, P., et al.
Publicado: (1981)

Response of remission lymphocytes to autochthonous leukaemic myeloblasts.
por: Taylor, G. M., et al.
Publicado: (1976)

Transcriptional network control of normal and leukaemic haematopoiesis
por: Sive, Jonathan I., et al.
Publicado: (2014)

The Effect of the Röntgen Ray upon Leukæmic States
Publicado: (1905)

Prediction of Psychosocial Sequelae in Families of Leukaemic Children
por: Culling, Janice, et al.
Publicado: (1988)

Influence of leukaemic cells on the colony formation of human bone marrow cells in vitro II. Suppressive effects of leukaemic cell extracts.
por: Chiyoda, S., et al.
Publicado: (1976)

Applications and analysis of targeted genomic sequencing in cancer studies
por: Bewicke-Copley, Findlay, et al.
Publicado: (2019)

Treatment of blast phase chronic myeloid leukaemia: A rare and challenging entity
por: Copland, Mhairi
Publicado: (2022)

Patterns of cyclic nucleotides in normal and leukaemic human leucocytes.
por: Peracchi, M., et al.
Publicado: (1980)

Clearance of immune complexes formed in normal and leukaemic rats.
por: Shepherd, P. S., et al.
Publicado: (1980)

Receptors for human immunoglobulin on acute myeloid leukaemic leucocytes.
por: Ridway, J. C., et al.
Publicado: (1976)

Cytotoxic effects on splenic ultrafiltrates upon leukaemic lymphocytes.
por: Attallah, A. M., et al.
Publicado: (1975)

Proceedings: Scanning electron microscopy of leukaemic and lymphoma cells.
por: de Harven, E.
Publicado: (1975)

Studies on the humoral regulation of granulopoiesis in leukaemic RFM mice.
por: Gordon, M. Y., et al.
Publicado: (1975)

Proceedings: Role of target cells in determining leukaemic characteristics.
por: Lajtha, L. G.
Publicado: (1975)

Exploration of the Lysis Mechanisms of Leukaemic Blasts by Chimaeric T-Cells
por: Laurin, David, et al.
Publicado: (2010)

Generalised Leukaemic Gingival Enlargement: a Case Report
por: Reenesh, Mechery, et al.
Publicado: (2012)

Myeloma-related disorder with leukaemic progression in a cat
por: Takeuchi, Yoshinori, et al.
Publicado: (2010)

Isolated CNS leukaemic relapse in acute myeloid leukaemia
por: Essa, Amr, et al.
Publicado: (2019)

Leukaemic Ascites and Peritoneal Myeloid Sarcoma: Rare but Not Impossible
por: Landeiro, Luís, et al.
Publicado: (2022)

Primary mesenchymal stromal cells in co-culture with leukaemic HL-60 cells are sensitised to cytarabine-induced genotoxicity, while leukaemic cells are protected
por: Gynn, Liana E, et al.
Publicado: (2021)

Combination of curaxin and tyrosine kinase inhibitors display enhanced killing of primitive Chronic Myeloid Leukaemia cells
por: Pearson, Stella, et al.
Publicado: (2022)

CD93 is expressed on chronic myeloid leukemia stem cells and identifies a quiescent population which persists after tyrosine kinase inhibitor therapy
por: Kinstrie, Ross, et al.
Publicado: (2020)

Correction: CD93 is expressed on chronic myeloid leukemia stem cells and identifies a quiescent population which persists after tyrosine kinase inhibitor therapy
por: Kinstrie, Ross, et al.
Publicado: (2020)

Assessment of drug sensitivity of human leukaemic myeloblasts. II. The toxic effects of cytosine arabinoside on 125IUdR-labelled human leukaemic myeloblasts in mice.
por: Sonis, S. T., et al.
Publicado: (1977)

Intracellular chemiluminescence activates targeted photodynamic destruction of leukaemic cells
por: Laptev, R, et al.
Publicado: (2006)

Characterisation of adriamycin- and amsacrine-resistant human leukaemic T cell lines.
por: Snow, K., et al.
Publicado: (1991)

Cannot write session to /tmp/vufind_sessions/sess_i8e5f19vaupn3pdeauci3hed22