DUX4 recruits p300/CBP through its C-terminus and induces global H3K27 acetylation changes

Ectopic expression of the double homeodomain transcription factor DUX4 causes facioscapulohumeral muscular dystrophy (FSHD). Mechanisms of action of DUX4 are currently unknown. Using immortalized human myoblasts with a titratable DUX4 transgene, we identify by mass spectrometry an interaction betwee...

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Detalles Bibliográficos
Autores principales: Choi, Si Ho, Gearhart, Micah D., Cui, Ziyou, Bosnakovski, Darko, Kim, Minjee, Schennum, Natalie, Kyba, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914088/
https://www.ncbi.nlm.nih.gov/pubmed/26951377
http://dx.doi.org/10.1093/nar/gkw141

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914088/
https://www.ncbi.nlm.nih.gov/pubmed/26951377
http://dx.doi.org/10.1093/nar/gkw141

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