Oxidized dNTPs and the OGG1 and MUTYH DNA glycosylases combine to induce CAG/CTG repeat instability

DNA trinucleotide repeat (TNR) expansion underlies several neurodegenerative disorders including Huntington's disease (HD). Accumulation of oxidized DNA bases and their inefficient processing by base excision repair (BER) are among the factors suggested to contribute to TNR expansion. In this s...

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Detalles Bibliográficos
Autores principales: Cilli, Piera, Ventura, Ilenia, Minoprio, Anna, Meccia, Ettore, Martire, Alberto, Wilson, Samuel H., Bignami, Margherita, Mazzei, Filomena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914090/
https://www.ncbi.nlm.nih.gov/pubmed/26980281
http://dx.doi.org/10.1093/nar/gkw170

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914090/
https://www.ncbi.nlm.nih.gov/pubmed/26980281
http://dx.doi.org/10.1093/nar/gkw170

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