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The PIN domain endonuclease Utp24 cleaves pre-ribosomal RNA at two coupled sites in yeast and humans

During ribosomal RNA (rRNA) maturation, cleavages at defined sites separate the mature rRNAs from spacer regions, but the identities of several enzymes required for 18S rRNA release remain unknown. PilT N-terminus (PIN) domain proteins are frequently endonucleases and the PIN domain protein Utp24 is...

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Detalles Bibliográficos
Autores principales: Wells, Graeme R., Weichmann, Franziska, Colvin, David, Sloan, Katherine E., Kudla, Grzegorz, Tollervey, David, Watkins, Nicholas J., Schneider, Claudia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914098/
https://www.ncbi.nlm.nih.gov/pubmed/27034467
http://dx.doi.org/10.1093/nar/gkw213