Combining structure probing data on RNA mutants with evolutionary information reveals RNA-binding interfaces

Systematic structure probing experiments (e.g. SHAPE) of RNA mutants such as the mutate-and-map (MaM) protocol give us a direct access into the genetic robustness of ncRNA structures. Comparative studies of homologous sequences provide a distinct, yet complementary, approach to analyze structural an...

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Detalles Bibliográficos
Autores principales: Reinharz, Vladimir, Ponty, Yann, Waldispühl, Jérôme
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Methods Online
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914100/
https://www.ncbi.nlm.nih.gov/pubmed/27095200
http://dx.doi.org/10.1093/nar/gkw217

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914100/
https://www.ncbi.nlm.nih.gov/pubmed/27095200
http://dx.doi.org/10.1093/nar/gkw217

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