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Combining structure probing data on RNA mutants with evolutionary information reveals RNA-binding interfaces

Systematic structure probing experiments (e.g. SHAPE) of RNA mutants such as the mutate-and-map (MaM) protocol give us a direct access into the genetic robustness of ncRNA structures. Comparative studies of homologous sequences provide a distinct, yet complementary, approach to analyze structural an...

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Detalles Bibliográficos
Autores principales:	Reinharz, Vladimir, Ponty, Yann, Waldispühl, Jérôme
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2016
Materias:	Methods Online
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914100/ https://www.ncbi.nlm.nih.gov/pubmed/27095200 http://dx.doi.org/10.1093/nar/gkw217

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