Distinct binding of BRCA2 BRC repeats to RAD51 generates differential DNA damage sensitivity

BRCA2 is a multi-faceted protein critical for the proper regulation of homology-directed repair of DNA double-strand breaks. Elucidating the mechanistic features of BRCA2 is crucial for understanding homologous recombination and how patient-derived mutations impact future cancer risk. Eight centrall...

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Detalles Bibliográficos
Autores principales: Chatterjee, Gouri, Jimenez-Sainz, Judit, Presti, Thomas, Nguyen, Tiffany, Jensen, Ryan B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914107/
https://www.ncbi.nlm.nih.gov/pubmed/27084934
http://dx.doi.org/10.1093/nar/gkw242

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914107/
https://www.ncbi.nlm.nih.gov/pubmed/27084934
http://dx.doi.org/10.1093/nar/gkw242

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