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Distinct binding of BRCA2 BRC repeats to RAD51 generates differential DNA damage sensitivity
BRCA2 is a multi-faceted protein critical for the proper regulation of homology-directed repair of DNA double-strand breaks. Elucidating the mechanistic features of BRCA2 is crucial for understanding homologous recombination and how patient-derived mutations impact future cancer risk. Eight centrall...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914107/ https://www.ncbi.nlm.nih.gov/pubmed/27084934 http://dx.doi.org/10.1093/nar/gkw242 |