Use of chemical modification and mass spectrometry to identify substrate-contacting sites in proteinaceous RNase P, a tRNA processing enzyme

Among all enzymes in nature, RNase P is unique in that it can use either an RNA- or a protein-based active site for its function: catalyzing cleavage of the 5′-leader from precursor tRNAs (pre-tRNAs). The well-studied catalytic RNase P RNA uses a specificity module to recognize the pre-tRNA and a ca...

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Detalles Bibliográficos
Autores principales: Chen, Tien-Hao, Tanimoto, Akiko, Shkriabai, Nikoloz, Kvaratskhelia, Mamuka, Wysocki, Vicki, Gopalan, Venkat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914120/
https://www.ncbi.nlm.nih.gov/pubmed/27166372
http://dx.doi.org/10.1093/nar/gkw391

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914120/
https://www.ncbi.nlm.nih.gov/pubmed/27166372
http://dx.doi.org/10.1093/nar/gkw391

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