Cre-dependent DNA recombination activates a STING-dependent innate immune response

Gene-recombinase technologies, such as Cre/loxP-mediated DNA recombination, are important tools in the study of gene function, but have potential side effects due to damaging activity on DNA. Here we show that DNA recombination by Cre instigates a robust antiviral response in mammalian cells, indepe...

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Detalles Bibliográficos
Autores principales: Pépin, Geneviève, Ferrand, Jonathan, Höning, Klara, Jayasekara, W. Samantha N., Cain, Jason E., Behlke, Mark A., Gough, Daniel J., G. Williams, Bryan R., Hornung, Veit, Gantier, Michael P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914124/
https://www.ncbi.nlm.nih.gov/pubmed/27166376
http://dx.doi.org/10.1093/nar/gkw405

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914124/
https://www.ncbi.nlm.nih.gov/pubmed/27166376
http://dx.doi.org/10.1093/nar/gkw405

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