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Cre-dependent DNA recombination activates a STING-dependent innate immune response
Gene-recombinase technologies, such as Cre/loxP-mediated DNA recombination, are important tools in the study of gene function, but have potential side effects due to damaging activity on DNA. Here we show that DNA recombination by Cre instigates a robust antiviral response in mammalian cells, indepe...
Autores principales: | Pépin, Geneviève, Ferrand, Jonathan, Höning, Klara, Jayasekara, W. Samantha N., Cain, Jason E., Behlke, Mark A., Gough, Daniel J., G. Williams, Bryan R., Hornung, Veit, Gantier, Michael P. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914124/ https://www.ncbi.nlm.nih.gov/pubmed/27166376 http://dx.doi.org/10.1093/nar/gkw405 |
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