Loss of p53-mediated cell-cycle arrest, senescence and apoptosis promotes genomic instability and premature aging

Although p53-mediated cell cycle arrest, senescence and apoptosis are well accepted as major tumor suppression mechanisms, the loss of these functions does not directly lead to tumorigenesis, suggesting that the precise roles of these canonical activities of p53 need to be redefined. Here, we report...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Tongyuan, Liu, Xiangyu, Jiang, Le, Manfredi, James, Zha, Shan, Gu, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Priority Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914251/
https://www.ncbi.nlm.nih.gov/pubmed/26943586
http://dx.doi.org/10.18632/oncotarget.7864

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914251/
https://www.ncbi.nlm.nih.gov/pubmed/26943586
http://dx.doi.org/10.18632/oncotarget.7864

Ejemplares similares