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Loss of p53-mediated cell-cycle arrest, senescence and apoptosis promotes genomic instability and premature aging
Although p53-mediated cell cycle arrest, senescence and apoptosis are well accepted as major tumor suppression mechanisms, the loss of these functions does not directly lead to tumorigenesis, suggesting that the precise roles of these canonical activities of p53 need to be redefined. Here, we report...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Impact Journals LLC
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914251/ https://www.ncbi.nlm.nih.gov/pubmed/26943586 http://dx.doi.org/10.18632/oncotarget.7864 |