Cargando…

Severe chronic cerebral hypoperfusion induces microglial dysfunction leading to memory loss in APPswe/PS1 mice

Cerebral vasculature plays a key role in controlling brain homeostasis. Cerebral vasculature dysfunction, associated to irregularities in cerebral blood perfusion, has been proposed to directly contribute to Alzheimer's disease (AD) pathogenesis. More precisely, chronic cerebral hypoperfusion,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bordeleau, Maude, ElAli, Ayman, Rivest, Serge
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper: Gerotarget (Focus on Aging)
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914254/ https://www.ncbi.nlm.nih.gov/pubmed/26918610 http://dx.doi.org/10.18632/oncotarget.7689

Ejemplares similares

Sub-acute systemic erythropoietin administration reduces ischemic brain injury in an age-dependent manner
por: Thériault, Peter, et al.
Publicado: (2016)

High fat diet exacerbates Alzheimer's disease-related pathology in APPswe/PS1 mice
por: Thériault, Peter, et al.
Publicado: (2016)

Mild chronic cerebral hypoperfusion induces neurovascular dysfunction, triggering peripheral beta-amyloid brain entry and aggregation
por: ElAli, Ayman, et al.
Publicado: (2013)

Splenocytes derived from young WT mice prevent AD progression in APPswe/PSENldE9 transgenic mice
por: Wang, Fei, et al.
Publicado: (2015)

Fluoxetine attenuates the impairment of spatial learning ability and prevents neuron loss in middle-aged APPswe/PSEN1dE9 double transgenic Alzheimer's disease mice
por: Ma, Jing, et al.
Publicado: (2017)

REM sleep behaviour disorder (RBD): risk for Parkinsonism and executive dysfunction in elderly
por: Lerche, Stefanie, et al.
Publicado: (2018)

Neuroendocrine immunomodulation network dysfunction in SAMP8 mice and PrP-hAβPPswe/PS1(ΔE9) mice: potential mechanism underlying cognitive impairment
por: Wang, Jian-hui, et al.
Publicado: (2016)

Astaxanthin acts via LRP-1 to inhibit inflammation and reverse lipopolysaccharide-induced M1/M2 polarization of microglial cells
por: Wen, Xiaojun, et al.
Publicado: (2017)

Navβ2 knockdown improves cognition in APP/PS1 mice by partially inhibiting seizures and APP amyloid processing
por: Hu, Tao, et al.
Publicado: (2017)

Mitochondrial dysfunction and oxidative stress in aging and cancer
por: Kudryavtseva, Anna V., et al.
Publicado: (2016)

MeCP2 mediated dysfunction in senescent EPCs
por: Wang, Chunli, et al.
Publicado: (2017)

NOX4 downregulation leads to senescence of human vascular smooth muscle cells
por: Przybylska, Dorota, et al.
Publicado: (2016)

PTPRD silencing by DNA hypermethylation decreases insulin receptor signaling and leads to type 2 diabetes
por: Chen, Yng-Tay, et al.
Publicado: (2015)

Activation of the ATF2/CREB-PGC-1α pathway by metformin leads to dopaminergic neuroprotection
por: Kang, Hojin, et al.
Publicado: (2017)

DNA damage response (DDR) and senescence: shuttled inflamma-miRNAs on the stage of inflamm-aging
por: Olivieri, Fabiola, et al.
Publicado: (2015)

Rapid and simple detection of gero-suppressive agents
por: Darzynkiewicz, Zbigniew
Publicado: (2015)

WW domain-containing oxidoreductase in neuronal injury and neurological diseases
por: Chang, Hsin-Tzu, et al.
Publicado: (2014)

Understanding the gastrointestinal tract of the elderly to develop dietary solutions that prevent malnutrition
por: Rémond, Didier, et al.
Publicado: (2015)

Measuring refractive index distribution in the human eye lens
por: Pope, James M., et al.
Publicado: (2015)

Characterization and redox mechanism of asthma in the elderly
por: Zuo, Li, et al.
Publicado: (2016)

TGF-β1-Smad signaling pathways are not required for epidermal LC homeostasis
por: Li, Guihua, et al.
Publicado: (2016)

Reprogramming of energy metabolism as a driver of aging
por: Feng, Zhaoyang, et al.
Publicado: (2016)

The effect of resveratrol on beta amyloid-induced memory impairment involves inhibition of phosphodiesterase-4 related signaling
por: Wang, Gang, et al.
Publicado: (2016)

Extracellular truncated tau causes early presynaptic dysfunction associated with Alzheimer’s disease and other tauopathies
por: Florenzano, Fulvio, et al.
Publicado: (2017)

Aging-related dysregulation in enteric dopamine and angiotensin system interactions: implications for gastrointestinal dysfunction in the elderly
por: Garrido-Gil, Pablo, et al.
Publicado: (2018)

Lifelong challenge of calcium homeostasis in male mice lacking TRPV5 leads to changes in bone and calcium metabolism
por: van der Eerden, Bram C.J., et al.
Publicado: (2016)

Combined effects of aging and inflammation on renin-angiotensin system mediate mitochondrial dysfunction and phenotypic changes in cardiomyopathies
por: Burks, Tyesha N., et al.
Publicado: (2015)

Maternal high calorie diet induces mitochondrial dysfunction and senescence phenotype in subcutaneous fat of newborn mice
por: Lettieri-Barbato, Daniele, et al.
Publicado: (2017)

Association of serum levels of antibodies against MMP1, CBX1, and CBX5 with transient ischemic attack and cerebral infarction
por: Wang, Hao, et al.
Publicado: (2017)

Autophagy flux induced by ginsenoside-Rg3 attenuates human prion protein-mediated neurotoxicity and mitochondrial dysfunction
por: Moon, Ji-Hong, et al.
Publicado: (2016)

Differentially expressed lncRNAs and miRNAs with associated ceRNA networks in aged mice with postoperative cognitive dysfunction
por: Wei, Changwei, et al.
Publicado: (2017)

De novo HAPLN1 expression hallmarks Wnt-induced stem cell and fibrogenic networks leading to aggressive human hepatocellular carcinomas
por: Mebarki, Sihem, et al.
Publicado: (2016)

Gavage of D-Ribose induces Aβ-like deposits, Tau hyperphosphorylation as well as memory loss and anxiety-like behavior in mice
por: Wu, Beibei, et al.
Publicado: (2015)

The anti-aging effects of LW-AFC via correcting immune dysfunctions in senescence accelerated mouse resistant 1 (SAMR1) strain
por: Wang, Jianhui, et al.
Publicado: (2016)

Metformin regulates oxLDL-facilitated endothelial dysfunction by modulation of SIRT1 through repressing LOX-1-modulated oxidative signaling
por: Hung, Ching-Hsia, et al.
Publicado: (2016)

Protective effect of APOE epsilon 2 on intrinsic functional connectivity of the entorhinal cortex is associated with better episodic memory in elderly individuals with risk factors for Alzheimer's disease
por: Chen, Jiu, et al.
Publicado: (2016)

Deletion of the γ-secretase subunits Aph1B/C impairs memory and worsens the deficits of knock-in mice modeling the Alzheimer-like familial Danish dementia
por: Biundo, Fabrizio, et al.
Publicado: (2016)

Association between gray matter atrophy, cerebral hypoperfusion, and cognitive impairment in Alzheimer’s disease
por: Dong, Haoyang, et al.
Publicado: (2023)

Multifocal Cerebral Microinfarcts Modulate Early Alzheimer’s Disease Pathology in a Sex-Dependent Manner
por: Lecordier, Sarah, et al.
Publicado: (2022)

The role of ABCB1 and ABCA1 in beta-amyloid clearance at the neurovascular unit in Alzheimer's disease
por: ElAli, Ayman, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_2tr9lsgh0r0kolg9u44b7k5mq7