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REST alleviates neurotoxic prion peptide-induced synaptic abnormalities, neurofibrillary degeneration and neuronal death partially via LRP6-mediated Wnt-β-catenin signaling
Prion diseases are a group of infectious neurodegenerative diseases characterized by multiple neuropathological hallmarks including synaptic damage, spongiform degeneration and neuronal death. The factors and mechanisms that maintain cellular morphological integrity and protect against neurodegenera...
Autores principales: | Song, Zhiqi, Zhu, Ting, Zhou, Xiangmei, Barrow, Paul, Yang, Wei, Cui, Yongyong, Yang, Lifeng, Zhao, Deming |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914267/ https://www.ncbi.nlm.nih.gov/pubmed/26919115 http://dx.doi.org/10.18632/oncotarget.7640 |
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