NOTUM is a potential pharmacodynamic biomarker of Wnt pathway inhibition

Activation of Wnt signaling due to Wnt overexpression or mutations of Wnt pathway components is associated with various cancers. Blocking Wnt secretion by inhibiting PORCN enzymatic activity has shown efficacy in a subset of cancers with elevated Wnt signaling. Predicting response to upstream Wnt in...

Descripción completa

Detalles Bibliográficos
Autores principales: Madan, Babita, Ke, Zhiyuan, Lei, Zheng Deng, Oliver, Frois Ashley, Oshima, Masanobu, Lee, May Ann, Rozen, Steve, Virshup, David M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914292/
https://www.ncbi.nlm.nih.gov/pubmed/26848981
http://dx.doi.org/10.18632/oncotarget.7157

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914292/
https://www.ncbi.nlm.nih.gov/pubmed/26848981
http://dx.doi.org/10.18632/oncotarget.7157

Ejemplares similares